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Metoclopramide 10mg tabletes, a new antidepressant has emerged on the scene: quetiapine is a selective (i.e., only inhibits monoamine oxidase, a oxidase inhibitor) and potent inhibitor of 5-HT2A receptors. This study aimed to investigate the efficacy of quetiapine in two mood disorders, major depressive disorder (MDD) and non-manic (NMDD), in a double-blind, placebo-controlled, active-controlled design in patients with moderate to severe MDD. Patients with a Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) diagnosis of MDD were randomized to receive either quetiapine (n=20) or Deflamat 75 kaufen placebo (n=20). The primary efficacy analyses included those patients whose baseline HAM-D score was greater than 12 (HAM-D12 score ≥13) at baseline and their HAM-D15 scores (score ≤12 and ≥13 at baseline) week 24. Secondary efficacy analyses included all patients whose baseline HAM-D12 score was greater than 11, HAM-D15 score ≤11 at week 24, and the Buy viagra online for cheap number of HAM-D12 or HAM-D15 units (both ≥2) at week 24. Patients randomized to quetiapine had a significant reduction in HAM-D15 scores (p=0.000) at week 24 compared with placebo. At week 24, the efficacy of quetiapine was also found in patients with depression classified as "mild" or "moderate"- moderate depression in either the DSM-IV DSM-IV-TR (p=0.02) or ICD-10 International Statistical Classification of Diseases and Related Health Problems (ICD-10) (p=0.02) criteria. The efficacy of quetiapine was also found in all patients remission for at least 90 days. There were no major safety concerns. These results indicate that quetiapine is a safe and effective antidepressant with adequate efficacy in MDD and NMDD.
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